منابع مشابه
Oxidative metabolism in cancer
STAT3 and STAT5 (STAT3/5) proteins are crucial mediators of cytokine- or growth factor-induced cell survival and proliferation. These transcription factors are frequently overactivated in a variety of solid tumors and hematopoietic neoplasms and are targets of various oncogenes with tyrosine kinase activity. STAT3/5 proteins regulate expression of genes involved in survival and proliferation in...
متن کاملEffect of maternal variable stress on oxidative status and glucose metabolism in pubertal male rats
Introduction: Metabolic disorders are affected by negative stress experiences in the early stages of life. Accordingly, in this study, the effects of stress during pregnancy on oxidative status and glucose homeostasis in pubertal male Wistar rats were investigated. Materials and Methods: After pregnancy, female rats (200±30 g) were divided into 2 groups (6 rats per group) of stress and non-stre...
متن کاملOxidative Metabolism Genes Are Not Responsive to Oxidative Stress in Rodent Beta Cell Lines
Altered expression of oxidative metabolism genes has been described in the skeletal muscle of individuals with type 2 diabetes. Pancreatic beta cells contain low levels of antioxidant enzymes and are particularly susceptible to oxidative stress. In this study, we explored the effect of hyperglycemia-induced oxidative stress on a panel of oxidative metabolism genes in a rodent beta cell line. We...
متن کاملOxidative Stress and Redox-Signaling in Renal Cell Cancer
Worldwide, approximately 150,000 people are diagnosed with Renal Cell Carcinoma (RCC) and 78,000 deaths are reported each year with the incidence on the rise (Jemel et al, 2010). Renal tumors are classified according to the “Heidelberg classification” where the tumors are separated based on their location within the nephron and linked to morphologic and genetic abnormalities (Schullerus et al, ...
متن کاملPersistent oxidative stress in cancer.
DNA of cancers such as renal cell carcinoma and mammary invasive ductal carcinoma, is persistently exposed to more oxidative stress than that of adjacent normal tissue. We suggest that the concept of 'persistent oxidative stress in cancer' may open up a new research area, explaining part of the characteristic tumor biology of cancer such as activated transcription factors and proto-oncogenes, g...
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ژورنال
عنوان ژورنال: Antioxidants
سال: 2021
ISSN: 2076-3921
DOI: 10.3390/antiox10050642